Covid 19 Vaccines affect on IVF treatment cycles

Take a look at Prof. Orvieto's latest academic work in the fertility field


Israel was at the forefront of the initial COVID 19 vaccination program and was the first country in the world to have a high vaccination rate. Prof Orvieto and the team investigated whether receiving a COVID-19 vaccine influence patients ‘cycle outcomes during IVF treatments. Patients cycle outcome was examined in a cycle before and after receiving the vaccine.

Here is what they found out:

  • In the present study, we could not demonstrate any detrimental effect of mRNA SARS-CoV-2vaccine on ovarian reserve/ oocytes (eggs) pool, as reflected by the similar response to ovarian stimulation- which is considered the " most reliable sign of decrease ovarian reserve.
  • In the present study, mRNA SARS-CoV-2 vaccine showed no detrimental effect on patients' total motile count (a sperm quality parameter).
  • In the present study we observed no influence of mRNA SARS-CoV-2vaccine on patients’ performance during their immediate subsequent IVF cycle, reflecting no detrimental effects of the vaccine on patients’ ovarian reserve, nor the developing gametes/embryos.

Our take home message:

Each donor coming to our clinic is encouraged to receive the mRNA SARS-CoV-2 vaccine to protect her health if she hasn't received it before. Vaccines are now provided in our clinic to assure easy-access and no wait for our donors.


Orvieto R, Noach-Hirsh M, Segev-Zahav A, Haas J, Nahum R, Aizer A. Does mRNA SARS-CoV-2 vaccine influence patients’ performance during IVF-ET cycle? Reprod Biol Endocrinol. 2021;19(1):1–4.